I tried Bryan Johnson’s Blueprint Longevity Mix — My honest review

Who doesn’t want to shed a few years?

I’m still in my twenties and feel healthy enough to survive the hustle and bustle of New York City. But, this idea of reversing the clock has been scratching my mind lately. Ever since I watched “Don’t Die” on Netflix, I’ve wondered, Can you really turn back the hands of time?

Anti-aging biohacker Bryan Johnson seems to think the answer to my question is yes, and claims that his Blueprint Protocol could be key to unlocking more years. So I did what I had to do. I drank the Kool-Aid, in the form of his almost-$50, hot pink Longevity Mix sold on Amazon. Will it add years to my life? I’m not sure yet. But, I do have some other reflections to share.

I know I’m not alone in my fear of aging.

For centuries, our culture has been oriented around preserving youth, both mentally and physically — especially for women subject to severe beauty trends portrayed on social media. But, the idea of age reversal goes deeper than the surface, and longevity experts are turning to science to slow down aging on a cellular level.

Johnson is among the fanatics pioneering a new school of thought devoted to prolonging the healthspan — that is the number of healthy years we have here on earth, free of major disease or disability. The entrepreneur knocks out roughly $2 million a year on his sometimes controversial health regimen, which includes 91 supplements, daily light therapy, nerve stimulation, and once — even swapping plasma with his 17-year-old son.

Hoping to share his youth-preserving routine with the public, Johnson released his line of Blueprint products on Amazon. The assortment includes $41 cocoa powder and $35 cold-pressed olive oil, in addition to multivitamins, NAC supplements, and other capsules that tout some remarkable benefits. For those looking to max out their health mission, there is a $195 Supplement Stack, which consists of a month-long supply of a supplement drink and 8 daily pills.

Not ready to go full-Bryan, or even half-Bryan for that matter, I decided to try out the best-selling Longevity Mix, which is said to condense over 20 capsules aimed at promoting better sleep, reducing stress, boosting energy, and is described by the brand as “everything your body asked for.”

Blueprint suggests waiting 90 days to achieve the results, but I’ve only been taking the Longevity Mix for a couple of weeks and there are already a few noticeable changes that have shocked me.

I’ve outlined the results of my experiment below. I’ve also consulted a Registered Dietitian Nutritionist, Melanie Murphy Richter, to separate fact from fiction — and help me understand how the Blueprint Longevity Mix is impacting me.

The BluePrint Longevity Mix is packed with some familiar ingredients and others I struggle to pronounce – Creatine, Calcium, Vitamin C, Ashwagandha, L-Theanine, Glutathione reduced, Sodium Hyaluronate, Lysine, Taurine. The combination of the above promises some astounding results, such as deeper sleep, enhanced muscle recovery, and even better focus. It sounds almost too good to be true.

Serving Size: One level scoop | Calories: 30 | Directions: Take just one scoop a day

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Blueprint Longevity Mix Review

First and foremost, the effects are not immediate.

The first week, I added a scoop of Longevity Mix to my banana-apple smoothie every morning, and I noticed nothing. My sleep schedule was still wonky, my energy the same, mood stable, but not better, by any means. I suspected that this also had to do with the fact that I wasn’t making many other lifestyle changes that Johnson would probably recommend — such as going to bed earlier, getting daily sunlight, and so on.

But with time and patience came more interesting findings.

One night, I hit my mattress hard and woke up the next day to my alarm blazing, something that hadn’t happened for at least two years. Usually, my body goes on auto-pilot and wakes me up before it sounds. But this night, I slept so deeply that my body didn’t flinch, and when I did finally wake up, I wasn’t even tired. In fact, I was energized and ready to start my day.

My new sleep cycle became quite consistent, and by the end of the second week, I felt like I was flying out of bed ready to tackle the day — typing faster at work, putting in more reps at the gym, and running on the energy of a 12-year-old. Placebo or not, I was pretty astounded with the results. I probably have not been using the Longevity Mix long enough to experience some of the other long-term benefits, but the improvement in sleep and energy is enough to encourage me to stay consistent with it.

My only gripe with the Longevity Mix has nothing to do with its quality or the potency of the ingredients. The formula mixes easily into liquids, but the taste is underwhelming, to say the least; bland, bitter, somewhat medicinal. I’m not alone in that opinion. One reviewer described the flavor as “God awful,” and “hard to swallow.” I’d strongly suggest that Johnson revise the taste profile, not just so it’s a touch more palatable, but also to expand the flavor offerings beyond blood orange and pineapple yuzu.

The Final Verdict

Besides my single subjective qualm, I’d say I’m quite satisfied with the Longevity Mix. I haven’t observed any physical changes since I started taking it, but the internal benefits — especially improved sleep and energy — are astounding. I’ve also come to terms with the almost-$50 price tag. The seemingly unending list of “powerhouse” ingredients replaces the need to pop a handful of pills in the morning. In that regard, it’s much more bang for your buck.

Blueprint Longevity Mix FAQs

The Post consulted Registered Dietitian Nutritionist Melanie Murphy Richter for insights on Bryan Johnson’s longevity mix. Murphy Richter has a Master’s in Nutrition, Healthspan, and Longevity from the Longevity Institute at the University of Southern California, and specializes in fasting, longevity science, and metabolic health.

Blueprint longevity mix ingredients: What do they do?

“Several key ingredients in this formulation stand out for their roles in cellular health, metabolism, and stress resilience,” shared Murphy Richter.

Below, she has broken down the different roles of specific ingredients in the mix, which may be less widely known than some other common names. These include L-glutathione, Creatine Monohydrate, Calcium Alpha-Ketoglutarate, L-theanine, and Taurine.

“Additional ingredients, such as vitamin C and magnesium citrate, contribute to immune function and nervous system regulation, while glucosamine sulfate and sodium hyaluronate are often included for joint and connective tissue support,” she added.

• Reduced L-Glutathione (GSH): “Often referred to as the body’s ‘master antioxidant,’ glutathione plays a crucial role in cellular detoxification, immune support, and oxidative stress reduction —important factors in longevity. The inclusion of the reduced form is notable, as this is the bioactive form that can be more efficiently utilized by the body compared to other forms requiring conversion.”
• Creatine Monohydrate: “Well-researched for its benefits in muscle function and cognitive health, creatine supports ATP production, the primary energy source for cells. While widely recognized for its role in athletic performance, it is also gaining attention for its potential neuroprotective effects, particularly as part of healthy aging strategies.”
• Calcium Alpha-Ketoglutarate (Ca-AKG): “A compound involved in cellular metabolism, Ca-AKG has been studied for its potential role in mitochondrial function and metabolic efficiency. Some early research suggests it may play a role in longevity by influencing energy pathways.”
• L-Theanine: “An amino acid naturally found in green tea, L-Theanine has been shown to promote relaxation and focus without sedation. It may also support sleep quality by modulating stress-related brain activity.”
• Taurine: “Recognized for its role in cardiovascular and mitochondrial function, taurine is emerging as a compound of interest in longevity research, particularly in relation to metabolic regulation. Some studies suggest that taurine levels decline with age, making it a relevant nutrient for longevity support.”

Could the Blueprint Longevity Mix be an effective supplement for people looking to support longevity?

“This blend includes ingredients that support key aspects of health, such as mitochondrial function, oxidative stress reduction, and metabolic balance — important factors in longevity,” Murphy Richter said. “However, true longevity isn’t achieved through supplementation alone.”

For optimal results, she has also recommended a nutrient-rich diet, regular physical activity, effective stress management, quality sleep, strong social connections, and periodic fasting, which activates the body’s natural repair mechanisms, including autophagy.

Autophagy is a critical cellular process that removes damaged components and recycles them to support cellular renewal — it plays a key role in slowing aging, protecting against disease, and maintaining metabolic efficiency, according to Murphy Richter.

“While some ingredients in this blend, such as Ca-AKG and glutathione, may support cellular function, they do not replicate the biological benefits of fasting, nutrient timing, or other well-established longevity practices,” she mentioned.

What are other lifestyle changes that can support longevity?

“A growing body of research underscores the role of nutritional interventions and fasting protocols in supporting cellular health. While supplementation can be a useful addition, it is most effective when paired with holistic, evidence-based lifestyle strategies,” she affirmed.

Murphy Richter explained believes that regular movement, stress resilience, and strong community relationships have been consistently linked to both lifespan and healthspan: “Without addressing these foundational pillars of longevity, supplementation alone is unlikely to create a meaningful long-term impact.”

Is there anyone who should avoid this supplement? Are there any potential side effects?

As with any dietary supplement, individual considerations should be taken into account. Murphy Richter has noted that individuals with kidney concerns should consult a healthcare provider before taking creatine, as it may increase the workload on the kidneys. She also suggested that those with shellfish allergies should verify the source of glucosamine sulfate, as some forms are derived from shellfish.

Murphy Richter also outlined a few potential side effects: “Magnesium citrate may have a mild laxative effect in sensitive individuals, L-theanine may have calming effects that could interact with blood pressure medications, and Allulose, while often well-tolerated, may cause mild digestive discomfort in larger amounts.”

How We Tested

I’ve spent over two weeks testing the Blueprint Longevity Mix, and have evaluated the product based on several measures. I tested for taste and consistency, tapped an expert to analyze the quality of the ingredients, took note of any noticeable internal and external effects, and considered the overall value of the product.

• Taste and Consistency: While taste preference is a subjective measure, I shared my notes on the overall taste profile and read reviews to gauge the overall opinion on the blood orange flavor. I also tested to see how well the mix dissolved into water and smoothies.
• Quality of the Ingredients: I spoke with a longevity expert to evaluate the quality and potency of the ingredients in the Longevity Mix, and to better understand the desired effects of each ingredient.
• Internal Effects: Based on my testing, I’ve made note of any changes in my routine — including sleep patterns and habits, stress levels, overall mood, muscle soreness, appetite, and energy. I’ve also scanned other customer reviews for indications of other internal effects.
• External Effects: While testing, I’ve been looking for any noticeable visible changes to my skin texture, hair growth, weight changes, or bloating. I’ve also scanned other customer reviews for indications of other external effects.
• Overall Value: I considered the price point of the Blueprint Longevity Mix — at nearly $50 — and stacked it up with some other multivitamins that I have taken. While more expensive than some others I’ve tested, the wider range of potent ingredients may justify the cost.

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