Jonathan Loaisiga is already back on the injured list.
The Yankees reliever landed on the 60-day IL on Friday morning with a right flexor strain after making three appearances in the first week of the season.
Dennis Santana was called up from Triple-A Scranton/Wilkes-Barre ahead of Friday’s home opener against the Blue Jays.
Loaisiga, who will now be sidelined until at least June, has been one of the Yankees’ top bullpen arms in recent years but he has not been able to stay healthy.
He missed time last year with two IL stints for elbow inflammation, including one that required surgery in May to remove bone spurs from his elbow.
The 29-year-old Loaisiga, a free agent after this season, has also missed time with shoulder troubles.
The Yankees had planned to use Loaisiga in a multi-inning role with multiple days built in between each outing.
But he threw two innings on Opening Day last Thursday, then one inning last Sunday and one inning Wednesday.
He had not allowed a run in four innings but gave up seven hits and one walk while striking out three.
Without Loaisiga, the Yankees will likely have to lean more on Ian Hamilton, Caleb Ferguson and Nick Burdi as setup men before getting the ball to Clay Holmes.
